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CNR1 gene is associated with high neuroticism and low agreeableness and interacts with recent negative life events to predict current depressive symptoms.

Juhasz, G., D. Chase, E. Pegg, D. Downey, Z. Tóth, K. Stones, H. Platt, K. Mekli, A. Payton, R. Elliott, et al., "CNR1 gene is associated with high neuroticism and low agreeableness and interacts with recent negative life events to predict current depressive symptoms.", Neuropsychopharmacology, vol. 34: Nature Publishing Group, pp. 2019–2027, February, 2009.